Steven L. Marks, BVSc, MS, MRCVS, DACVIM, Clinical Professor of Emergency and Internal Medicine; Associate Dean and Director of Veterinary Medical Services, North Carolina State College of Veterinary Medicine
Nonregenerative anemias can be caused by nutritional deficiencies, chronic disease, renal disease, and primary bone marrow diseases. Acute anemia will be nonregenerative until regeneration occurs in 3–4 days.
A 10-year-old, male-castrated golden retriever has a 1-month history of mild lethargy and decreased appetite. On physical examination, he has pale mucous membranes and weak femoral pulses. His complete blood count (CBC) shows a decreased packed cell volume (PCV), decreased mean corpuscular volume (MCV), and decreased mean corpuscular hemoglobin concentration (MCHC). His biochemistry panel shows a mildly increased blood urea nitrogen (BUN) level and mildly increased serum alkaline phosphatase (ALP) level. Which of the following is the most likely cause of this dog’s anemia?