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Fungal Infections in Cats

By Otto M. Radostits, CM, DVM, MSc, DACVIM (Deceased), Professor Emeritus, Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan ; Max J. Appel, DMV, PhD, Professor Emeritus ; David A. Ashford, DVM, MPH, DSc, Assistant Area Director, International Services, APHIS, USDA ; Stephen C. Barr, BVSc, MVS, PhD, DACVIM, Professor of Medicine, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University ; J. P. Dubey, MVSc, PhD, Microbiologist, Animal Parasitic Diseases Laboratory, Beltsville Agricultural Research Center, USDA ; Paul Ettestad, DVM, MS, State Public Health Veterinarian, Epidemiology and Response Division, New Mexico Department of Health ; Craig E. Greene, DVM, MS, Professor, Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia ; Delores E. Hill, PhD, Parasitologist, U.S. Department of Agriculture ; Johnny D. Hoskins, DVM, PhD, Small Animal Consultant ; Eugene D. Janzen, DVM, MVS, Professor, Production Animal Health, Faculty of Veterinary Medicine, University of Calgary ; Jodie Low Choy, BVSc, BVMS, IVAS Cert, Menzies School of Health Research; University Avenue Veterinary Hospital, Northern Territory, Australia ; Dennis W. Macy, MS, DACVIM, Professor of Medicine and Oncology, College of Veterinary Medicine and Biomedical Sciences,Colorado State University ; Dudley L. McCaw, DVM, DACVIM (Small Animal, Oncology), Professor, Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University ; Barton W. Rohrbach, VMD, MPH, DACVPM, Associate Professor, Department of Comparative Medicine, Veterinary Teaching Hospital, University of Tennessee ; J. Glenn Songer, PhD, Professor, Department of Veterinary Science and Microbiology, University of Arizona ; Richard A. Squires, BVSc (Hons), PhD, DVR, DACVIM, DECVIM-CA, GCertEd, MRCVS, Head of Veterinary Clinical Sciences, School of Veterinary and Biomedical Sciences, James Cook University ; Bert E. Stromberg, PhD, Professor, Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota ; Joseph Taboada, DVM, DACVIM, Professor and Associate Dean, Office of Student and Academic Affairs, School of Veterinary Medicine, Louisiana State University ; Charles O. Thoen, DVM, PhD, Professor, Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University ; John F. Timoney, MVB, PhD, Dsc, MRCVS, Keeneland Chair of Infectious Diseases, Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky ; Ian Tizard, BVMS, PhD, DACVM, University Distinguished Professor of Immunology; Director, Richard M. Schubot Exotic Bird Health Center, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University

Also see professional content regarding fungal infections.

Funguses (also called fungi) are parasitic, spore-producing organisms. They obtain their nourishment by absorbing food from the hosts on which they grow. Many species of fungus exist in the environment, but only some cause infections. The primary source of most infections is soil. Fungal infections can be acquired by inhalation, ingestion, or through the skin (for example, through a cut or wound).

Some fungal infections can cause disease in otherwise healthy animals, while others require a host that is sick, weakened, or immunocompromised to establish infection. Prolonged use of antibiotic drugs or immunosuppressive agents appears to increase the likelihood of some fungal infections. The infection itself may be localized, or it may affect the entire body. In general, fungal infections affecting the skin (such as ringworm) are common in cats, while generalized fungal infections are very rare.

Aspergillosis

Aspergillosis is a fungal infection caused by several Aspergillus species. It is primarily a respiratory infection that may become generalized. Aspergillosis is found worldwide and in almost all domestic animals as well as in many wild animals; however, the susceptibility to fungal infections varies among species. Nasal cavity, lung, and intestinal forms have been described in domestic cats. Cats that are already stressed by disease (such as viral infection) or immunosuppressed may be more likely to become infected. Signs are nonspecific and include inflammation of the sinuses or the esophagus (or both) and pneumonia. Establishing an accurate diagnosis can be difficult. Surgery and antifungal drugs are usually recommended to treat aspergillosis; however, the outlook depends on the overall condition of the cat and the extent of infection.

Candidiasis

Candidiasis is a localized fungal disease affecting the mucous membranes and the skin. It is distributed worldwide in a variety of animals and is most commonly caused by species of the yeast-like fungus, Candida albicans. Candidiasis is rare in cats, but has been associated with oral and upper respiratory disease, lesions of the eye, infection of the space between the lungs and chest wall, intestinal disease, and bladder infection.

Factors that may predispose an animal to infection include injury to any of the mucous membranes, the use of catheters, administration of antibiotics, and immunosuppressive drugs or diseases.

Signs of infection are variable and nonspecific (for example, diarrhea, weakness, skin lesions) and may be associated more with the primary or predisposing conditions than with the Candida infection itself. An ointment or topical application may be useful in the treatment of oral or skin candidiasis. Your veterinarian may also recommend different drugs given by mouth or by injection for treatment of infected cats.

Coccidioidomycosis (Valley Fever)

Coccidioidomycosis is a dustborne, noncontagious infection caused by the fungus Coccidioides immitis. Infections are limited to dry, desertlike regions of the southwestern United States and similar geographic areas of Mexico and Central and South America. Inhalation of fungal spores (often carried on dust particles) is the only established mode of infection. Epidemics may occur when rainy periods are followed by drought, resulting in dust storms. Infections are uncommon in cats.

Coccidioidomycosis is primarily a chronic respiratory disease. Infected cats most often have skin problems (draining skin lesions, lumps under the skin, abscesses), fever, lack of appetite, and weight loss. Less common signs in cats include difficulty breathing, lameness, neurologic signs, and eye abnormalities. A diagnosis is based on identification of the fungus in tissue samples from the animal.

Treatment involves longterm antifungal medications. The prognosis is guarded, but cats with skin infections may respond to treatment. There is no known prevention other than decreasing your pet’s exposure to desert soil and dust as much as possible.

Cryptococcosis

Cryptococcosis is a fungal disease that may affect the respiratory tract (especially the nasal cavity), central nervous system, eyes, and skin (particularly of the face and neck of cats). It is caused by the fungus Cryptococcus neoformans, which is found worldwide in soil and bird manure, especially in pigeon droppings. Transmission is by inhalation of spores or contamination of wounds.

Cryptococcosis is most common in cats, although it also occurs in other domestic and wild animals. In cats, upper respiratory signs following infection of the nasal cavity are most common. The signs often include sneezing, bloody nasal discharge, polyp-like mass(es) in the nostril, and a firm swelling under the skin and over the bridge of the nose. Areas of small raised bumps and nodules may affect the skin; these may feel soft (liquid filled) or firm. These areas may ulcerate, leaving a raw surface. Neurologic signs associated with cryptococcosis of the central nervous system include depression, changes in temperament, seizures, circling, slight paralysis, and blindness. Eye abnormalities may also develop.

Various antifungal drugs may be prescribed for the treatment of cryptococcosis. Most affected pets require prolonged treatment (up to several months), depending on the severity and extent of the disease. Treatment for cryptococcosis may include surgery to remove lesions in the nasal cavity or on the bridge of the nose. The outlook for cats that are also infected with feline leukemia virus or feline immunodeficiency virus is guarded, because these cats have a higher likelihood of treatment failure.

Histoplasmosis

Histoplasmosis is a noncontagious infection caused by the fungus Histoplasma capsulatum, which is found worldwide. This soil fungus is widely distributed (particularly by bird and bat populations) in the midwestern and southern United States, especially in river valleys and plains. Infection occurs when spores in the air are inhaled. The lungs and the lymph nodes in the chest are the sites of primary infection. The organisms enter the bloodstream from these sites and become dispersed throughout the body; they may localize in bone marrow or the eyes.

The signs vary and are nonspecific, reflecting the various organ involvements. Occasionally, cats with lung involvement show signs of fever, labored breathing, and coughing. The lung infection usually resolves on its own. However, if the respiratory infection extends to other tissues, a more serious form of the disease may develop, involving a large number of organs and body systems. The organs most often involved are the lungs, intestine, lymph nodes, liver, spleen and bone marrow. Signs of illness such as depression, fever, and poor appetite are common, as well as chronic diarrhea, intestinal blood loss, anemia, and weight loss. Infection of the bones, eyes, skin, and central nervous system may occur. Diagnosis requires identification of the fungus in body fluids or tissues.

Treatment of widespread histoplasmosis is difficult. It requires the use of antifungal drugs and supportive treatment such as adequate nutrition, additional fluids (hydration), and control of secondary bacterial infections. Antifungal treatment must be continued for prolonged periods of time and may be expensive.

Mycetomas

Mycetomas are infections of the skin and underlying tissues that have the appearance of nodules or tumors. When such lesions are caused by funguses, they are known as eumycotic mycetomas. The fungus multiplies in the lesions and organizes into aggregates known as granules or grains. Granules may be of various colors and sizes, depending on the species of fungus involved. Mycetomas are rare in cats.

Most eumycotic mycetomas are confined to the tissue beneath the skin. In cats, mycetomas are usually characterized by skin nodules on the legs and feet or on the face. When the feet or limbs are involved, the infection may extend to the underlying bone. Skin mycetomas, while not life-threatening, are often difficult to resolve. Your veterinarian will recommend the best treatment options, which may include surgical removal or antifungal medication.

North American Blastomycosis

North American blastomycosis, caused by the fungus Blastomyces dermatitidis, is generally limited to geographically restricted areas in the Mississippi, Missouri, Tennessee, and Ohio River basins and along the Great Lakes and the St. Lawrence Seaway. Beaver dams and other habitats where soil is moist, acidic, and rich in decaying vegetation may serve as the ecologic niche for the organism, which has also been found in pigeon and bat feces. Blastomycosis is rare in cats.

Affected animals have signs such as fever, lethargy, poor appetite, and weight loss. Lung involvement leads to exercise intolerance, cough, and difficulty breathing. The peripheral lymph nodes may be enlarged. Bone involvement may occur and result in lameness. Central nervous system infection may lead to behavior changes, seizures, coma, or sudden death. Infection of the urogenital tract occasionally may occur and cause signs such as blood in the urine or difficulty urinating. Eye involvement can lead to pain, light sensitivity, and glaucoma. Involvement of the retina may lead to blindness. Draining nodules may be found in the skin.

Treatment of blastomycosis is based on the severity of the condition and other factors that must be evaluated by a veterinarian. Treatment is aimed at relief of specific signs (such as difficulty breathing, coughing, or eye problems) and elimination of the fungus from the body. Treatment may include one or more antifungal drugs, which are given for an extended period (often 2 months or more) until active disease is not apparent. Relapses may occur (Veterinary.heading on page Fungal Infections in Dogs : North American Blastomycosis).

Phaeohyphomycosis

Phaeohyphomycosis is a general term for an infection by any of a number of pigmented funguses of the family Dematiaceae. Infection may result from fungal contamination of tissue at the site of an injury. Phaeohyphomycosis is uncommon in cats. In most cases, the infection is confined to the skin and tissues beneath the skin. Slowly enlarging masses beneath the skin are found on the head, the lining of the nasal passages, limbs, and chest. The nodules may ulcerate and have draining tracts. Surgical removal of the lesion can be a cure. Treatment with antifungal drugs may be considered in cases when surgery is not possible.

Rhinosporidiosis

Rhinosporidiosis is a chronic, nonfatal infection, primarily of the lining of the nasal passages and, occasionally, of the skin. It is caused by the fungus Rhinosporidium seeberi. Uncommon in North America, it is seen most often in India, Africa, and South America.

Infection is characterized by polyp-like growths that may be soft, pink, crumbly, lobular with roughened surfaces, and large enough to obstruct or close off the nasal passages. The skin lesions may be single or multiple, attached at a base, or have a stem-like connection.

Surgical removal of the lesions is considered to be the standard treatment, but recurrence is common.

Sporotrichosis

Sporotrichosis is a sporadic chronic disease caused by Sporothrix schenckii. The organism is found around the world in soil, vegetation, and timber. In the US, this fungus is most commonly found in coastal regions and river valleys. Infection usually results when the organism enters the body through skin wounds via contact with plants or soil or penetrating foreign objects such as a sharp branch. Transmission of the disease from animals to humans can occur.

Sporotrichosis is more common in cats than other species. The infection may remain localized to the site of entry (involving only the skin) or it may spread to nearby lymph nodes. Although generalized illness is not seen initially, longterm infection may result in fever, listlessness, and depression. Rarely, infection will spread through the bloodstream from the initial site of inoculation to the bone, lungs, liver, spleen, testes, gastrointestinal tract, or central nervous system.

Longterm treatment with antifungal drugs (continued 3 to 4 weeks beyond apparent cure) is usually recommended. Because sporotrichosis can be passed from your pet to you, strict hygiene must be observed when handling animals with suspected or diagnosed sporotrichosis. If your cat is diagnosed with sporotrichosis, ask your veterinarian about the precautions you and every member of your family should take while your pet is ill.

Also see professional content regarding fungal infections.

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