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Find information on animal health topics, written for the veterinary professional.

Amino-acetonitrile Derivatives

By Jozef Vercruysse, DVM, Professor, Faculty of Veterinary Medicine, Ghent University
Edwin Claerebout, DVM, PhD, DEVPC, Professor, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University

Amino-acetonitrile derivatives are a class of synthetic compounds with high activity against GI nematodes, including isolates resistant to all other commercially available broad-spectrum anthelmintic classes, because of their novel mode of action. Efficacy studies have shown that monepantel (2.5 mg/kg, PO) effectively controls adult and L4 stages of ruminant nematodes, including strains that are resistant or multidrug resistant to the other currently available broad-spectrum anthelmintic classes.