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| Disposition and Fate of Drugs: Overview |  |
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| Once a drug has been administered by any route other than IV, it must be absorbed into the bloodstream from the site of administration. The drug then is distributed into various body fluids and tissues to attain an effective, yet safe, concentration for a sufficient period of time at the site of action. Subsequently, the drug is inactivated or eliminated from the body, generally by metabolism (usually lipid-soluble drugs) and excretion (mainly renal and biliary routes). The effectiveness of these processes with respect to time (pharmacokinetics) varies with the particular drug and species of animal. It is equally influenced by disease and the effects of concurrently administered agents (drug interactions). |
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| See Also |
| Introduction |
| Disposition and Fate of Drugs |
| Drug Absorption |
| Drug Distribution |
| Drug Biotransformation |
| Drug and Metabolite Excretion |
| Pharmacokinetics |
| Overview |
| Drug Concentration in Blood |
| Apparent Volume of Distribution |
| Drug Clearance (Elimination) |
| Drug Action and Pharmacodynamics |
| Overview |
| Drug Concentration and Effect |
| Agonists and Antagonists |
| Structure-activity Relationships |
| Signal Transduction and Drug Action |
| Drug Dose and Clinical Response |
| Dosage Forms and Delivery Systems |
| Overview |
| Oral Dosage Forms and Delivery Systems |
| Oral Modified-release Delivery Systems |
| Parenteral Dosage Forms and Delivery Systems |
| Topical Dosage Forms and Delivery Systems |
| Chemical Residues in Food and Fiber |
| Overview |
| Chemical Residues in Foodstuffs of Animal Origin |
| Chemical Residues in Animal Fibers |
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