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Therapeutic Indications and Dose Rates |  |
| The imidazoles are used to treat systemic fungal diseases, dermatomycoses that have not responded to griseofulvin or topical therapy,
Malassezia
in dogs, aspergillosis, and sporotrichosis in animals that cannot tolerate or do not respond to sodium iodide. For serious infections, combination with amphotericin B is strongly recommended. Among the imidazoles, fluconazole is most indicated for tissues that are tough to penetrate. Both itraconzaole and fluconazole are generally preferred to other imidazoles for treatment of systemic fungal infections, including aspergillosis and sporotrichosis. Topically applied
imidazoles (clotrimazole, miconazole, econazole) are used for local dermatophytosis. Thiabendazole is included in some otic preparations for treatment of yeast infections. |
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Enilconazole is an imidazole that can be applied topically for the treatment of dermatophytosis and aspergillosis. It has been used safely in cats, dogs, cattle, horses, and chickens and is prepared as a 0.2% solution for the treatment of fungal skin infections. When infused into the nasal turbinates of dogs with aspergillosis, enilconazole treated and prevented the recurrence of fungal disease. When applied topically to dog and cat hairs
enilconazole inhibits fungal growth in 2 rather than 4-8 treatments, as is necessary with other topically administered antifungal agents. |
| General dosages for the antifungal imidazoles are listed in Table:
Dose Rates of Imidazoles. The dose rate and frequency should be adjusted as needed for the individual animal. |
