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Therapeutic Indications and Dose Rates |  |
| The more common indications for flucytosine include cryptococcal meningitis, used together with amphotericin B (~30% of the isolates develop resistance during the course of treatment); candidiasis (~90% of isolates are usually sensitive); aspergillosis (some strains are sensitive at <5 µg/mL); chromomycosis (some strains are very sensitive); and sporotrichosis (some cases may respond). |
| General dosages for flucytosine are 25-50 mg/kg and 30-40 mg/kg, PO, tid-qid in dogs and cats, respectively. The dose rate and frequency should be adjusted as needed for the individual animal. Dosage modification is essential in renal failure. Flucytosine serum levels should be monitored if possible. |
