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Special Clinical Concerns |  |
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Side Effects and Toxicity: |
| Side effects induced by griseofulvin are rare. Nausea, vomiting, and diarrhea have been seen. Hepatotoxicity has also been reported. Animals with impaired liver function should not be given griseofulvin because its biotransformation will be reduced and toxic levels may be reached. Idiosyncratic toxicity in cats has been reported. Griseofulvin is contraindicated in pregnant animals (especially mares and queens) because it is teratogenic. |
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Interactions: |
| Lipids increase the GI absorption of griseofulvin. Barbiturates decrease its absorption and antifungal activity. Griseofulvin is a microsomal enzyme inducer and promotes the biotransformation of many concurrently administered drugs. The combined use of ketoconazole and griseofulvin may lead to hepatotoxicity. |
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Effects on Laboratory Tests: |
| Alkaline phosphatase, AST, and ALT increase. Proteinuria may be detected. |
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