Hypercalcemia Associated with Hypoadrenocorticism

Mild hypercalcemia (≤15 mg/dL) has been reported in up to 30% of dogs with hypoadrenocorticism (Addison’s disease). Multiple factors may result in the hypercalcemia, including increased calcium citrate (complexed calcium), hemoconcentration (relative increase), increased renal resorption of calcium, and increased affinity of serum proteins for calcium. Although total serum calcium concentrations may be increased, the ionized fraction usually is normal. The hypercalcemia resolves quickly with successful treatment for hypoadrenocorticism.