| Panosteitis is a spontaneous, self-limiting disease of young, rapidly growing, large and giant dogs that primarily affects the diaphyses and metaphyses of long bone. The exact etiology is unknown, although genetics (in German Shepherds), stress, infection, and metabolic or autoimmune causes have been suspected. The pathophysiology of the disease is characterized by intramedullary fat necrosis, excessive osteoid production, and vascular congestion. Endosteal and periosteal bone
reactions occur. |
| Clinical signs are acute, cyclical, and involve single or multiple bone(s) in dogs 6-16 mo old. Animals are lame, febrile, inappetent, and have palpable long bone pain. Radiography reveals increased multifocal, intramedullary densities and irregular endosteal surfaces along long bones. Therapy is aimed at relieving pain and discomfort; oral NSAID or corticosteroids can be used during periods of illness. Excessive dietary supplementation in young, growing dogs should be avoided. |
