Nodular hyperplasia has been described as a benign, age-related change in dogs. It is usually associated with a VH and may be confused histologically with hepatic adenoma. Nodular hyperplasia does not cause clinical disease but is accompanied by increased liver enzyme activity, particularly AP. Unless the liver is diffusely remodeled with nodular lesions (secondary to degenerative VH), TSBA concentrations remain normal. Ultrasonographically, nodular hyperplasia is associated with hypoechoic hepatic nodules set against a hyperechoic background. Cytology of an aspirate may discriminate neoplastic cells or inflammatory cells but cannot rule out either disorder. Biopsy is necessary for differentiation between mass regenerative nodules, cirrhosis, or neoplasia.
Last full review/revision March 2012 by Sharon A. Center, DVM, DACVIM