THE MERCK VETERINARY MANUAL
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Great Dane Myopathy

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Inherited myopathy of Great Danes is a noninflammatory condition of young Great Danes. Affected dogs have been identified in England, Australia, and Canada. An autosomal recessive mode of inheritance is suspected. Clinical signs include exercise-induced tremors, weakness, and muscle wasting. CK activity is usually increased, fibrillation potentials are detected in skeletal muscles, and histopathology reveals a central core myopathy. Treatment is supportive, at best.

Last full review/revision May 2013 by Joseph Harari, MS, DVM, DACVS

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