THE MERCK VETERINARY MANUAL
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Trauma of the Spinal Column and Cord

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Acute spinal cord injuries are commonly associated with spinal fracture or luxation. Common causes in dogs and cats are automobile accidents, bite wounds, and gunshot wounds. Falls are common causes in horses. Cattle are susceptible to injuries from breeding. Pathologic fractures are common in cattle, sheep, and pigs with malnutrition or vertebral osteomyelitis. Damage to the spinal cord is caused not only by the primary mechanical injury but also as a result of secondary pathologic changes, including edema, hemorrhage, demyelination, and necrosis. These secondary changes are due to biochemical factors, including the release of free radicals, leukotrienes, and prostaglandins that cause further injury to nervous tissue and compromise blood flow to the spinal cord.

Signs of spinal trauma are typically acute and may progress in instances of unstable fractures or luxations. Severe thoracolumbar spinal cord injury may cause paraplegia with increased extensor tone in the thoracic limbs (Schiff-Sherrington phenomenon). Radiographs usually demonstrate vertebral fractures and luxations. However, in dogs with trauma, radiographs, compared with CT, reveal only ~75% of spinal fractures, so advanced imaging is indicated in animals with suspected spinal trauma and normal radiographs. Treatment with methylprednisolone may be helpful for animals with severe neurologic deficits if instituted within the first few hours of injury. One protocol is 30 mg/kg, IV, followed 2 hr later by 15 mg/kg, IV, followed 6 hr later by 15 mg/kg, IV, every 6 hr for a total of 24 hr of treatment. Dexamethasone is less effective and is associated with an increased risk of GI ulceration and pancreatitis. NSAIDs have minimal benefit in acute spinal cord injury and increase the risk of complications, especially if used in conjunction with corticosteroids. DMSO (0.5–1 g/kg/day of a 10%–20% solution, given slowly IV for 3 days) is recommended in horses with acute spinal cord injury. Animals with mild neurologic deficits often recover with 4–6 wk of cage or stall rest and analgesics. Surgical reduction and stabilization is indicated for unstable vertebral injuries causing severe neurologic dysfunction. The prognosis is guarded for recumbent horses and cattle. In animals that have lost deep pain perception caudal to the lesion, the prognosis for return of neurologic function is poor.

Last full review/revision October 2013 by William B. Thomas, DVM, MS, DACVIM (Neurology)

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