Praziquantel and epsiprantel are closely related analogs that have high efficacy against cestode parasites at relatively low dose rates but no effect on nematodes.
Praziquantel PO is highly effective against cestodes of ruminants (eg, Moniezia spp, Stilesia), horses (Anoplocephala perfoliata), dogs, cats, and poultry. The PO (5 mg/kg), SC (5.8 mg/kg), or spot-on (cats, 12 mg/kg) administration of praziquantel in dogs and cats is 100% effective against Dipylidium caninum, Taenia spp, and Echinococcus spp (both adult and immature forms). Praziquantel at a dosage of 40 mg/kg is also effective against Schistosoma infections in cattle (and people).
Epsiprantel at 5 mg/kg is used specifically for the treatment of the common tapeworms of dogs and cats, including adult E granulosus.
Last full review/revision September 2014 by Jozef Vercruysse, DVM; Edwin Claerebout, DVM, PhD, DEVPC