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Find information on animal health topics, written for the veterinary professional.

Amino-acetonitrile Derivatives

By Jozef Vercruysse, DVM, Professor, Faculty of Veterinary Medicine, Ghent University ; Edwin Claerebout, DVM, PhD, DEVPC, Professor, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University

Amino-acetonitrile derivatives are a class of synthetic compounds with high activity against GI nematodes, including isolates resistant to all other commercially available broad-spectrum anthelmintic classes, because of their novel mode of action. Efficacy studies have shown that monepantel (2.5 mg/kg, PO) effectively controls adult and L4 stages of ruminant nematodes, including strains that are resistant or multidrug resistant to the other currently available broad-spectrum anthelmintic classes.