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Find information on animal health topics, written for the veterinary professional.

Streptogramins

By Dawn Merton Boothe, DVM, PhD, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

The streptogramin antibiotics include two distinct groups. Group A contain a 23-membered unsaturated ring with lactone and peptide bonds, and group B are depsipeptides (lactone-cyclized peptides). These antibiotics are included in the macrolide-lincosamide-streptogramin (MLS) group. However, whereas the individual A and B components act in a bacteriostatic fashion when used as sole agents, together the affinity for the ribosome is enhanced, causing them to be bactericidal. Streptogramins include virginiamycin. Streptogramins are used to treat vancomycin-resistant staphylococci and Enterococcus faecium.