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Haemoproteus Infection in Poultry

By Arnaud J. Van Wettere, DVM, MS, PhD, DACVP, Assistant Professor of Veterinary Pathology, Utah Veterinary Diagnostic Laboratory, School of Veterinary Medicine, Utah State University

Haemoproteus spp is the most common blood parasite in birds, especially nondomestic birds. More than 120 species have been reported. Haemoproteus spp are found in free-living ducks, quail, and turkeys but are rare to absent in commercial flocks, probably because of limited vector exposure or very specific feeding habits of Culicoides spp and hippoboscid flies, the invertebrate vectors. Haemoproteus is considered nonpathogenic in most avian species. Birds are usually asymptomatic; however, Haemoproteus infection may be more often significant than previously thought, based on increasing reports documenting decreased host fitness, nestling mortalities, fledging success, and delayed recovery in infected birds versus uninfected birds. Anemia, anorexia, weight loss, and depression have been reported. Rarely fatal disease occurs. Clinical disease is usually attributed to anemia, presence of megaloschizonts in the musculature, or host-cell destruction.

In poultry, infection with H lophortyx in bobwhite quail caused clinical disease and increased mortality with as much as 20% flock loss. Quail 5–10 wk old were usually affected, and clinical signs included reluctance to move, prostration, and death. Gross lesions included congested spleen and liver and hemorrhagic streaks in the muscles. Histology revealed myositis with megaloschizonts in the musculature, especially of the legs and back, and hemosiderin accumulation in the splenic macrophages. Experimental infection in turkeys with H meleagridis resulted in lameness, diarrhea, anorexia, and depression. Histologic lesions were associated mainly with megaloschizont development in the musculature. Infection in racing pigeons (called pigeon malaria) is commonly asymptomatic but often blamed for poor performances that are due to other diseases or inadequate housing and management. Clinical disease in Columbiformes is rare.

Diagnosis is made by examination of stained blood smears and observation of large, pigmented gametocytes in mature RBCs that partially or occasionally completely encircle the nucleus without displacing it. Merozoites are not seen in the peripheral blood. Schizogony within the endothelial cells of the lung, liver, and spleen may be seen histologically. PCR tests for Haemoproteus have been developed. Little is known about effective treatment. Antimalarial drugs reduce the parasitemia but do not eliminate the parasite. Chloroquine, primaquine, quinacrine, and buparvaquone have been used in pigeons. Combinations of chloroquine and primaquine or chloroquine and mefloquine have been used to treat owls. Treatment is not recommended in asymptomatic birds. Measures to control invertebrate vectors, such as screening of aviaries, help prevent transmission and heavy infections.

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