Merck Manual

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Pharmacokinetics of Selected Fluoroquinolones

Pharmacokinetics of Selected Fluoroquinolones

Drug

Species

Elimination Half-life (hr)

Volume of Distribution (L/kg)

Clearance (mL/min/kg)

Enrofloxacin

Cats

7

4.3

Dogs

4.4

3.7

11

Mares

4–7

2

0.5–4

Marbofloxacin

Dogs

12

2

1.5

Orbifloxacin

Cats

4.5

1.3

Dogs

5.4

1.2