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Drug
Uses
Comments
Tricyclic antidepressants
Amitriptyline
Anxiety, compulsive disorders
Cheaper than many other drugs, but may be more likely to cause adverse effects
Clomipramine
Anxiety, aggression, compulsive disorders
FDA approved for use in separation anxiety in dogs
Selective serotonin reuptake inhibitors
Fluoxetine
May take 3 to 4 weeks before affecting behavior; also FDA approved for treating separation anxiety in dogs
Paroxetine
Sertraline
Azapirones
Buspirone
Anxiety
Benzodiazepines
Alprazolam
Thunderstorm phobia, anxiety
Longer acting than other drugs of this class
Diazepam
Anxiety, noise phobia
May cause physical dependence
Monoamine oxidase inhibitors
Selegiline
FDA approved for use in cognitive dysfunction in dogs
Must not be combined with serotonin reuptake inhibitors or tricyclic drugs due to adverse drug interactions
