Merck Manual

Please confirm that you are a health care professional

Actions of Inflammatory Mediators

Actions of Inflammatory Mediators

Action

Mediatorsa

Vasodilation, increased vascular permeability

Histamine, serotonin, bradykinin, C3a, C5a, LTC4, LTD4, PGI2, PGE2, PGD2, PGF2, activated Hageman factor, kinonogen fragments, fibrinopeptides

Vasoconstriction

TXA2, LTB4, LTC4, LTD4, C5a

Smooth muscle contraction

C3a, C5a, histamine, LTB4, LTC4, LTD4, TXA2, serotonin, PAF, bradykinin

Mast cell degranulation

C5a, C3a

Stem cell proliferation

IL-3, G-CSF, GM-CSF, M-CSF

Chemotaxis

C5a, LTB4, IL-8, PAF, 5-HETE, histamine, others

Lysosomal granule release

C5a, IL-8, PAF

Phagocytosis

C3b, iC3b

Platelet aggregation

TXA2, PAF

Endothelial cell stickiness

IL-1, TNF-α, LTB4

Granuloma formation

IL-1, TNF-α

Pain

PGE2, bradykinin, histamine, serotonin

Fever

IL-1, IL-6, TNF-α, PGE2

a C = complement, LT = leukotriene, PG = prostaglandin, TX = thromboxane, PAF = platelet activating factor, IL = interleukin, CSF = colony stimulating factor, HETE = hydroxyeicosatetranoate, TNF = tumor necrosis factor