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1–2 mg/kg, PO, once to twice daily
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Maximal effects may require treatment for several weeks.
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Effects similar to those of amitriptyline but may be effective in some cases in which amitriptyline is not.
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2.5–4 mg/kg, PO, as needed
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Limited usefulness; most birds require a dose that causes sedation to inhibit plucking.
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0.15 mg/kg, PO, once to twice daily for larger birds; 0.2 mg/kg, PO, bid for smaller species
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Serious adverse effects, including anorexia, hepatic dysfunction, and CNS signs have been reported; most often used in cockatoos.
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2 mg/kg/day, PO, once to twice daily
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Effectiveness reported to vary; maximal effects may require treatment for several weeks.
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Medroxyprogesterone acetate
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Decreases sexual behavior; not recommended because of serious adverse effects, including weight gain, polyuria, polydipsia, lethargy, hepatopathy, diabetes mellitus, and death.
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GnRH agonist, eg, leuprolide acetate
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Decreases sexual behavior by negative feedback, reducing production of sex hormones.
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