Merck Manual

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Elimination, Distribution, and Clearance of Cephalosporins

Elimination, Distribution, and Clearance of Cephalosporins

Cephalosporin

Species

Elimination Half-life (min)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Cefazolin

Horses

45

188

5.5

Cefotaxime

Sheep

25

134

9.0

Cefpodoxime

Dog

300

150

Cefovecin

Dog

5.5 days

90

Cephalexin

Dogs

7.3–9 hr

Cefadroxil

Dogs

120

Cats

150–180

Ceftiofur

Cattle

~360