Merck Manual

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Elimination, Distribution, and Clearance of Tetracyclines

Elimination, Distribution, and Clearance of Tetracyclines

Tetracycline

Species

Elimination Half-life (hr)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Oxytetracycline

Dogs

6

3,000

4.23

Calves (<3 mo old)

10–13

1,500–2,400

3.45

Cattle

7–10

800–1,000

3.33

Horses

8–10

1,100

2.89

Minocycline

Dogs

7

2,000

3.21

Doxycycline

Dogs

7–10

930

1.7

Cats

5

340

1.0

Horses

9