Merck Manual

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Dosages of Polyene Macrolide Antibiotics

Dosages of Polyene Macrolide Antibiotics

Polyene Macrolide

Dosage, Route, and Frequency

Amphotericin B (0.1 mg/mL in 5% dextrose)

0.1–1 mg/kg, given IV slowly, 3 times/wk

Total dose: 4–11 mg/kg

Amphotericin B lipid complex injection (Abelcet®)

1–3 mg/kg, IV, every other day or 3 times/wk

Total dose: 12–24 mg/kg

Amphotericin B liposome (AmBisome®)

3– 4 mg/kg, IV, every other day or 3 times/wk

Total dose: 12–30 mg/kg

Nystatin

50,000–150,000 U, PO, tid (dogs)

Pimaricin (5% ophthalmic solution)

1 drop, instilled into the eye, every 1–2 hr