Merck Manual

Please confirm that you are a health care professional

Oral Toxic Doses (TD) and Lethal Doses (LD) of Herbicides in Domestic Species

Oral Toxic Doses (TD) and Lethal Doses (LD) of Herbicides in Domestic Species

Compound

TD/LD

Species

Dosage (mg/kg)

Phenoxy acid derivatives

Phenoxy acid and its sodium salt

LD50

Chickens

547

Dogs

100–800

LD

Pigs

500

Hens

380–765

TD

Pigs

100

Calves

200

Butyl glycol ester

TD

Cattle

250 for 3 days

Sheep

250 for 2 days

Amine salts

TD

Cattle

250 for 10 days

Sheep

250 for 10 days or

Sheep

500 for 7 days

Bipyridyl compounds or quaternary ammonium

Paraquat

LD50

Dogs

25–50

Cats

35

Monkeys

50–70

Cattle

35–50

Chickens

110–360

LD

Sheep

8–10

Pigs

75

Diquat

LD50

Dogs

100–200

Cats

35–50

Cattle

20–40

Chickens

200–400

Ureas and thioureas

Diuron

TD

Cattle

100 for 10 days

Sheep

250 or 100 for 2 days

Chickens

50 for 10 days

Linuron

TD

Dogs

100–200

Cats

35–50

Cattle

20–40

Chickens

200–400

Tebuthiuron

LD50

Cats

>200

TD

Cats

200

LD50

Dogs

>500

TD

Dogs

50/day for 3 moa

Chickens, quail, or ducks

No deaths were reported at a dosage of 500 mg/kg body wt.

Protoporphyrinogen oxidase inhibitors

Metribuzin

LD50

Cats

>500

Anilide, acetamides, or amide compounds

Propanil

LD50

Dogs

1,217

Propyzamide

LD50

Dogs

>10,000

Dinitrophenolic compounds

DNOC

LD50

Hens

26

Dogs

50

Pigs

50

Goats

100

TD

Cattle

2–50

Sheep

20–50

LD

Sheep

25 for 5 days

Dinoseb

LD50

Hens

26

TD

Cattle

25 for 8 days

Sheep

25 for 10 days

Dinitroaniline

Trifluralin

LD50

Dogs

>2,000

Bromacil

TD

Cattle

250

Chickens

500 for 10 days

Sheep

50 for 10 days or 250 for 8 days

Carbamates and thiocarbamate compounds

Asulam

LD50

Rabbits

>2,000

Chickens

>2,000

Dogs

>5,000

Di-allate

LD50

Dogs

510

TD

Chickens

150 for 10 days or 250 for 7 days

Cattle

25 for 5 days or 50 for 3 days

Sheep

25 for 5 days or 50 for 3 days

Phenmedipham

LD50

Dogs

>4,000

LD50

Chickens

>3,000

Picrolinic acid derivative

Picloram

LD50

Cattle

>750

Sheep

>1,000

a Anorexia and weight loss reported. No deaths were reported in dogs at a tebuthiuron dosage of 500 mg/kg body wt.