Merck Manual

Please confirm that you are a health care professional

Drugs for Intestinal Helminths of Dogs Approved in the USA and UK

Drugs for Intestinal Helminths of Dogs Approved in the USA and UK

Drug/Drug Combination

Dosage (mg/kg)

Route of Administration

Helminths Active Againsta

Approved only in USA

Fenbendazole

50, daily for 3 days

PO

Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala, Trichuris vulpis, Trichuris pisiformis

Epsiprantel

5.5

PO

D caninum, T pisiformis

Milbemycin oxime

0.5

PO

T canis, T leonina, A caninum, T vulpis

Milbemycin oxime + spinosad

0.5/30

PO

T canis, T leonina, A caninum, T vulpis

Moxidectin

0.17

SC

A caninum, U stenocephala

Piperazine (various salts)

48–66b, d

PO

T canis, T leonina

Praziquantel

5–12.5

PO

D caninum, T pisiformis, Echinococcus granulosusc, E multilocularisc

5–11.4

SC, IM

D caninum, T pisiformis, E granulosus, E multilocularis

Pyrantel pamoate

5 (10 for dogs ≤2.3 kg)

PO

T canis, T leonina, A caninum, U stenocephala

Ivermectin + pyrantel pamoate

0.006/5

PO

T canis, T leonina, A caninum, A braziliense, U stenocephala

Praziquantel + pyrantel pamoate

5/5

PO

T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis

Praziquantel + pyrantel pamoate + febantel

5/5/25

PO

T canis, T leonina, A caninum, U stenocephala, T vulpis, D caninum, T pisiformis, E granulosus, E multilocularis

Praziquantel + pyrantel pamoate + ivermectin

5/5/0.006

PO

T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis

Approved only in UK

Fenbendazole

100; 50, daily for 3 days

PO

T canis, T leonina, Ancylostoma spp, Uncinaria spp, Trichuris spp, Taenia spp

Praziquantel

5

PO

D caninum, T pisiformis, Taenia multiceps, T hydatigena, T ovis, E granulosus, E multilocularis

Selamectin

6

Topical

T canis

Febantel + pyrantel embonate

15/14.4

PO

T canis, T leonina, A caninum, U stenocephala, T vulpis

Milbemycin oxime + praziquantel

0.5/5

PO

T canis, T leonina, A caninum, T vulpis, D caninum, Taenia spp, Echinococcus spp, Mesocestoides spp

Praziquantel + pyrantel embonate + febantel

5/14.4/15

PO

T canis, T leonina, A caninum, U stenocephala, T vulpisc, D caninumc, Taenia spp (T hydatigenac, T pisiformisc), Echinococcus sppc (E granulosusc, E multilocularisc)

Praziquantel + pyrantel embonate + oxantel embonate

5/5/20

PO

T canis, T leonina, A caninum, U stenocephala, T vulpis, D caninum, Taenia sppc (Taenia ovisc, T pisiformisc, T hydatigenac, T multicepsc), Echinococcus sppc (E granulosusc, E multilocularisc), Mesocestoides sppc

Approved both in USA and UK

Milbemycin oxime + lufenuron

0.5/10

PO

T canis, T leoninad, A caninum, T vulpis

Moxidectin + imidacloprid

2.5/10

Topical

T canis, T leonina, A caninum, U stenocephala, T vulpis, Spirocerca lupie

a Many of these drugs are also approved for use against other types of parasites (eg, fleas, heartworm) not listed here.

b Repeat in 10–20 days

c Only some products

d Only in the USA

e Only in the UK