Merck Manual

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Novobiocin Sodium

By

Dawn Merton Boothe

, DVM, PhD, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

Last full review/revision Nov 2015 | Content last modified Nov 2015

Novobiocin is a narrow-spectrum antibiotic that may be bacteriostatic or bactericidal at higher concentrations. It is active mostly against gram-positive bacteria but also against a few gram-negative bacteria. There is a synergistic effect with tetracyclines. Many species of bacteria can develop resistance to novobiocin. Adverse reactions are quite frequent after administration. Its main use is in combination with other agents for treatment of bovine mastitis.

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