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Drug
Dosage
Schedule
l-Asparaginase
10,000 IU/m2, SC
Wk 1
Vincristine
0.5–0.7 mg/m2, IV
Wk 1, 3, 6, 8, 11, 13, 16, and 18
Cyclophosphamide
250 mg/m2, IV or PO
Wk 2, 7, 12, and 17
Doxorubicin
30 mg/m2, IV, for dogs >10 kg; 1 mg/kg for dogs <10 kg
Wk 4, 9, 14, and 19
Prednisone
2 mg/kg/day, PO
For first week, then 1.5 mg/kg/day, PO, for 7 days, then 1 mg/kg/day, PO, for 7 days, then 0.5 mg/kg/day, PO, for 7 days, then discontinue.
