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Elimination, Distribution, and Clearance of Cephalosporins

Elimination, Distribution, and Clearance of Cephalosporins

Cephalosporin

Species

Elimination Half-life (min)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Cefazolin

Horses

45

188

5.5

Cefotaxime

Sheep

25

134

9.0

Cefpodoxime

Dog

300

150

Cefovecin

Dog

5.5 days

90

Cephalexin

Dogs

7.3–9 hr

—

—

Cefadroxil

Dogs

120

—

—

Cats

150–180

—

—

Ceftiofur

Cattle

~360

—

—

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Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.  The Merck Veterinary Manual was first published in 1955 as a service to the community.  The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.

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