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Dosage Modifications of Aminoglycosides in Renal Failure

Dosage Modifications of Aminoglycosides in Renal Failure

Increase in Normal Serum or Plasma Creatinine (mg/dL)

Dose and Dosage Interval

<1

Full dose at usual dosage interval

2-fold increase

Full dose at usual dosage interval or increased to 50% plus usual dosing interval (eg, 36 hr)

3- to 4-fold increase

Full dose, doubling usual dosage interval

>4-fold increase

Aminoglycosides contraindicated

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Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.  The Merck Veterinary Manual was first published in 1955 as a service to the community.  The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.

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