Table: Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals - Merck Veterinary Manual

Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals

Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals

Drug	Suggested Dosage	Typical Antimicrobial Activity
Amoxicillin	11 mg/kg, PO, bid-tid	Staphylococci, streptococci, enterococci, Proteus, some E coli
Ampicillin	25 mg/kg, PO, tid	Staphylococci, streptococci, enterococci, Proteus, some E coli
Amoxicillin-clavulanic acid	25 mg/kg, PO, tid	Staphylococci, streptococci, enterococci, Proteus, some E coli
Cephalexin/cefadroxil	20–30 mg/kg, PO, bid-tid	Staphylococci, streptococci, Proteus, E coli, Klebsiella
Cefovecin	8 mg/kg, SC, every 14 days	Proteus, E coli
Cefpodoxime	5–10 mg/kg/day, PO	Proteus, E coli
Ceftiofur	2 mg/kg/day, SC	Proteus, E coli
Choramphenicol	Dogs: 25–50 mg/kg, PO, bid-tid Cats: 50 mg/kg, PO, bid	Staphylococci, streptococci, enterococci, E coli
Doxycycline	5 mg/kg, PO, bid	Streptococci, some activity against E coli, staphylococci, and enterococci at high urine concentrations
Enrofloxacin, orbifloxacin, marbofloxacin, pradofloxacin (cats only)	2.5–10 mg/kg/day, PO	Staphylococci, E coli, Proteus, Klebsiella, Pseudomonas, Enterobacter
Gentamicin	4–6 mg/kg/day, SC	Staphylococci, some streptococci, some enterococci, E coli, Proteus, Klebsiella, Pseudomonas, Enterobacter
Nitrofurantoin	5 mg/kg, PO, tid	Staphylococci, some streptococci, enterococci, E coli, Klebsiella, Enterobacter
Tetracycline	18 mg/kg, PO, tid	Streptococci, some activity against E coli, staphylococci, and enterococci at high urine concentrations
Trimethoprim-sulfa	15 mg/kg, PO, bid	Streptococci, staphylococci, E coli, Proteus, some activity against Klebsiella