The streptogramin antibiotics include two distinct groups. Group A contain a 23-membered unsaturated ring with lactone and peptide bonds, and group B are depsipeptides (lactone-cyclized peptides). These antibiotics are included in the macrolide-lincosamide-streptogramin (MLS) group. However, whereas the individual A and B components act in a bacteriostatic fashion when used as sole agents, together the affinity for the ribosome is enhanced, causing them to be bactericidal. Streptogramins include virginiamycin. Streptogramins are used to treat vancomycin-resistant staphylococci and Enterococcus faecium.
OTHER TOPICS IN THIS CHAPTER
Antibacterial Agents
β-Lactam Antibiotics
Penicillins
Cephalosporins and Cephamycins
Aminoglycosides
Quinolones, including Fluoroquinolones
Sulfonamides and Sulfonamide Combinations
Tetracyclines
Phenicols
Macrolides
Streptogramins
Lincosamides
Polymyxins
Bacitracins
Glycopeptides
Fosfomycin
Novobiocin Sodium
Tiamulin Fumarate
Ionophores
Rifamycins
Nitrofurans
Nitroimidazoles
Hydroxyquinolines