Merck Manual

Please confirm that you are a health care professional

honeypot link
Causes of Hypercalcemia in Dogs and Cats

Causes of Hypercalcemia in Dogs and Cats


Apocrine gland adenocarcinoma

Carcinoma (squamous cell, mammary, bronchogenic, prostate, thyroid, nasal cavity)

Chronic and acute renal failure

Factitious: lipemia, postprandial, young dog (< 6 mo old)

Granulomatous disease

Hematologic malignancies (bone marrow osteolysis)

Humoral hypercalcemia

Hypercalcemia of malignancy


Hypervitaminosis D: iatrogenic, plants (eg, day-blooming jessamine), rodenticides, antipsoriatic cream

Hypoadrenocorticism (Addison disease)

Iatrogenic disorders: excess calcium or oral phosphate binders

Idiopathic hypercalcemia of cats

Laboratory error

Lymphoma (lymphosarcoma)

Metastatic or primary bone neoplasia

Multiple myeloma

Myeloproliferative disease (rare)

Primary hyperparathyroidism

Skeletal lesions: osteomyelitis, hypertrophic osteodystrophy