Merck Manual

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Drugs Used in Aquaculture in the USA – Approval Status and Withdrawal Times

Drugs Used in Aquaculture in the USA – Approval Status and Withdrawal Times

Active Ingredient

Trade Name

Generic Use

Application Method

Approval Statusa

Withdrawal Time

Florfenicol

Aquaflor®

Antibiotic

Medicated feed

FDA approveda (Veterinary Feed Directive)

15 days

Oxytetracycline dihydrate

Terramycin-200®

Antibiotic

Medicated feed

FDA approved

21 days

Ormetoprim sulfadimethoxine

Romet-30®

Antibiotic

Medicated feed

FDA approved

42 days in salmonids; 3 days in catfish

Hydrogen peroxide (35%)

PEROX-AID®

Antimicrobial (gills and skin only)

Immersion

FDA approved

None

Chloramine-T

HALAMID Aqua®

Antimicrobial (gills and skin only)

Immersion

FDA approved

None

Diquat

Reward®

Herbicide

Antibiotic (gills and skin only)

Immersion

Immersion

EPA

INAD required

5 days in channel catfish, muskellunge, tiger muskellunge, northern pike; 30 days in all others

Formalin

Formalin-FTM

Formalin-B

Parasite-S®

Parasiticide (gills and skin only)

Immersion

FDA approved

None

Copper sulfate (CuSO4)

Parasiticide (gills and skin only)

Immersion

INAD required

7 days

Potassium permanganate (KMnO4)

Parasiticide (gills and skin only)

Immersion

INAD required

7 days

Diflubenzuron

Dimilin®

Parasiticide (external crustaceans)

Immersion

EPAa (restricted use pesticide)

Not for use in food fish

Tricaine methanesulfonate

Tricaine-S®

Anesthetic

Immersion

FDA approved

21 days

Eugenol

Aqui-S20E®

Anesthetic

Immersion

INAD required

72 hours

Metomidate

Aquacalm®

Sedative

Immersion

The Index

Not for use in food fish

Chorionic gonadotropin

Chorulon®

Spawning aid

Injection

FDA approveda (prescription only)

None (broodstock)

sGnRHa + domperidone

Ovaprim®

Spawning aid

Injection

The Index

Not for use in food fish

a Approval status is of January 8, 2015. Practitioners should check the FDA Web site (www.fda.gov/AnimalVeterinary/ResourcesforYou/AnimalHealthLiteracy/ucm213944.htm) frequently for the most current information.