Merck Manual

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Characteristic Laboratory Abnormalities Associated with Common Causes of Hypercalcemia

Characteristic Laboratory Abnormalities Associated with Common Causes of Hypercalcemia

Diagnosis

Total Calcium

Ionized Calcium

Intact PTH

1,25-Dihydroxyvitamin D

Phosphorus

PTHrP

Primary hyperthyroidism

High

High

Normal to high

Normal

Normal to low

Negative

Malignant hypercalcemia

High

High

Low to low- normal

Low to normal

Normal to low

Positive (sometimes)

Hypoadrenocorticism (Addison disease)

Low, normal, or high

Normal

Normal

Normal

Normal to high

Negative

Chronic renal failure

Low, normal, or high

Normal to low

Normal to high

Low to normal

High

Negative

Hypervitaminosis D (calcitriol or calcitriol analogue)

High

High

Low to low- normal

Low to normal

Normal to high

Negative

Hypervitaminosis D (D2 or D3 toxicity)

High

High

Low to low- normal

High

Normal to high

Negative

Granulomatous disease

High

High

Low to low- normal

Low to normal

Normal to high

Negative

Idiopathic hypercalcemia of cats

High

High

Normal

Normal

Normal

Negative