Merck Manual

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Nonhuman Primate Therapeutics a

Nonhuman Primate Therapeutics a

Antibiotics

Amoxicillin

11 mg/kg/day, IM or SC; 11 mg/kg, PO, bid; 62.5 mg, PO, bid (lemurs)

Metronidazole

25–50 mg/kg, PO, bid for 10 days (gastroenteritis and inflammatory bowel disease)

Azithromycin

40 mg/kg, PO, once, then 20 mg/kg/day, PO, for 5 days

Cefazolin

25 mg/kg, IM or IV, bid for 10 days

Ceftriaxone

50–100 mg/kg, IM or IV, bid

Doxycycline

2.5 mg/kg, PO, bid for one day, then 2.5 mg/kg/day, PO

Minocycline

2–15 mg/kg/day, PO

Enrofloxacin

5 mg/kg, IM or PO, once to twice daily for 10 days

Erythromycin

30–50 mg/kg, IM or PO, bid-tid

Gentamicin

3–5 mg/kg, IM or IV, bid for 5-7 days

Penicillin G potassium + penicillin G benzathine

20,000–60,000 U/kg, IM, once to twice daily (higher dosage in lemurs)

Trimethoprim-sulfamethoxazole

15–50 mg/kg, PO or IM, bid; sulfamethoxazole at 20 mg/kg, PO, bid (higher dosages for lemurs)

Parasiticides

Fenbendazole

50 mg/kg/day, PO, for 5 days, repeated in 2 wk

Ivermectin

200–300 mcg/kg, SC, IM, or PO, repeated in 14 days

Mebendazole

22 mg/kg/day, PO, for 3 days, repeated in 14 days (for Giardia sp)

Metronidazole

30–50 mg/kg, PO, bid for 5–10 days

Praziquantel

5 mg/kg, IM, PO, or SC, once (15–20 mg/kg, PO or IM, for some cestodes; 40 mg/kg, PO or IM, for trematodes)

Thiabendazole

100 mg/kg, PO, once, repeated in 14 days (owl monkeys); 50 mg/kg/day, PO, for 2 days (Strongyloides); 75–100 mg/kg/day, PO, for 10 days (Entamoeba, Balantidium) in great apes

Anesthetics and Analgesics

Ketamine hydrochloride

10–15 mg/kg, IM, for restraint only; ketamine (15 mg/kg) with diazepam (1 mg/kg), IM, or ketamine (8 mg/kg) with midazolam (0.2–1 mg/kg), IM, for additional muscle relaxation

Ketoprofen

2 mg/kg/day, IV or IM

Inhalant gas (isoflurane, halothane)

1%–2%; maintenance of surgical plane of anesthesia

Flunixin meglumine (analgesic)

0.5– 2 mg/kg, IV, IM, or SC, bid

Buprenorphine

0.005–0.01 mg/kg, SC, IM, or IV, bid-qid (great apes)

0.015–0.02 mg/kg, IM, SC, tid-qid (New World primates)

Butorphanol tartrate

0.02 mg/kg, SC, qid (New World primates); 0.02 mg/kg (not to exceed 0.3 mg total), IM (chimpanzees); may cause profound respiratory depression

Dexmedetomidine

40 mcg/kg, IM, for anesthesia in combination with ketamine at 20–30 mcg/kg, IM (lemurs) or at 2–6 mg/kg, IM (macaques and baboons)

Midazolam

0.05–0.1 mg/kg, IV (slow) or IM: 0.1–0.5 mg/kg, IM (with ketamine helps prevent seizures in lemurs); 5 mg/animal, IM (chimpanzees)

Oxymorphone (opioid analgesic)

0.025–0.075 mg/kg, IM or IV, every 4–6 hr (New World primates); 0.15 mg/kg, SC, IM, or IV, every 4–6 hr (Old World primates); 1–1.5 mg/animal, SC or IM, every 4 hr (chimpanzees)

Propofol

2.5–5 mg/kg, IV bolus induction, 0.3–0.4 mg/kg/min constant-rate infusion (baboons and macaques); 7–8 mg/kg, IV bolus (marmosets, larger nonhuman primates); 1–2 mg/kg, IV bolus (chimpanzees), followed by infusion to effect; oxygen support always available

Tiletamine-zolazepam

3–5 mg/kg, IM, for restraint only (great apes), severe ataxia noted during recovery: 1–2.5 mg/kg, IM (New World primates); 1.5–3 mg/kg, IM (macaques)

a All are extra-label uses.