Merck Manual

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CHOP Multidrug Chemotherapy for Treatment of Canine Lymphoma

CHOP Multidrug Chemotherapy for Treatment of Canine Lymphoma

Drug

Dosage

Schedule

l-Asparaginase

10,000 IU/m2, SC

Wk 1

Vincristine

0.5–0.7 mg/m2, IV

Wk 1, 3, 6, 8, 11, 13, 16, and 18

Cyclophosphamide

250 mg/m2, IV or PO

Wk 2, 7, 12, and 17

Doxorubicin

30 mg/m2, IV, for dogs >10 kg; 1 mg/kg for dogs <10 kg

Wk 4, 9, 14, and 19

Prednisone

2 mg/kg/day, PO

For first week, then 1.5 mg/kg/day, PO, for 7 days, then 1 mg/kg/day, PO, for 7 days, then 0.5 mg/kg/day, PO, for 7 days, then discontinue.