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Merck Manual
Veterinary Manual
The trusted provider of veterinary information since 1955
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Veterinary /
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Elimination, Distribution, and Clearance of Penicillins

Elimination, Distribution, and Clearance of Penicillins

Penicillin

Species

Elimination Half-life (min)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Penicillin G

Dogs

30

156

3.6

Horses

38

301

5.5

Ampicillin

Dogs

48

270

3.9

Amoxicillin

Cattle

84

493

4.0

Ticarcillin

Dogs

48

347

4.9

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Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.  The Merck Veterinary Manual was first published in 1955 as a service to the community.  The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.

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