Merck Manual

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Elimination, Distribution, and Clearance of Penicillins

Elimination, Distribution, and Clearance of Penicillins

Penicillin

Species

Elimination Half-life (min)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Penicillin G

Dogs

30

156

3.6

Horses

38

301

5.5

Ampicillin

Dogs

48

270

3.9

Amoxicillin

Cattle

84

493

4.0

Ticarcillin

Dogs

48

347

4.9