Merck Manual

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Elimination, Distribution, and Clearance of Aminoglycosides

Elimination, Distribution, and Clearance of Aminoglycosides

Aminoglycoside

Species

Elimination Half-life (min)

Volume of Distribution (mL/kg)

Clearance (mL/kg/min)

Gentamicin

Dogs

75

335

3.10

Horses

110

190

1.23

Foals

200

300

1.04

Amikacin

Dogs

60

300

3.50

Horses

45

207

0.75

Sheep

115

200

0.70