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Increase in Normal Serum or Plasma Creatinine (mg/dL)
Dose and Dosage Interval
<1
Full dose at usual dosage interval
2-fold increase
Full dose at usual dosage interval or increased to 50% plus usual dosing interval (eg, 36 hr)
3- to 4-fold increase
Full dose, doubling usual dosage interval
>4-fold increase
Aminoglycosides contraindicated
