Merck Manual

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Dosage Modifications of Aminoglycosides in Renal Failure

Dosage Modifications of Aminoglycosides in Renal Failure

Increase in Normal Serum or Plasma Creatinine (mg/dL)

Dose and Dosage Interval

<1

Full dose at usual dosage interval

2-fold increase

Full dose at usual dosage interval or increased to 50% plus usual dosing interval (eg, 36 hr)

3- to 4-fold increase

Full dose, doubling usual dosage interval

>4-fold increase

Aminoglycosides contraindicated