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Polyene Macrolide
Dosage, Route, and Frequency
Amphotericin B (0.1 mg/mL in 5% dextrose)
0.1–1 mg/kg, given IV slowly, 3 times/wk
Total dose: 4–11 mg/kg
Amphotericin B lipid complex injection (Abelcet®)
1–3 mg/kg, IV, every other day or 3 times/wk
Total dose: 12–24 mg/kg
Amphotericin B liposome (AmBisome®)
3– 4 mg/kg, IV, every other day or 3 times/wk
Total dose: 12–30 mg/kg
Nystatin
50,000–150,000 U, PO, tid (dogs)
Pimaricin (5% ophthalmic solution)
1 drop, instilled into the eye, every 1–2 hr
