Merck Manual

Please confirm that you are a health care professional

Dosages of Antiviral Drugs

Dosages of Antiviral Drugs

Drug

Preparation

Dose, Route, and Frequency

Indication

Idoxuridine

0.1% ophthalmic solution

1 drop, topical, every 5–6 hr

0.5% ophthalmic solution

1 drop, topical, every 1–2 hr

Trifluridine

1% ophthalmic solution

1 drop, topical, every 2 hr initially (2 days), then 3–8 times daily

Ocular herpesvirus infection

Vidarabine

3% ophthalmic solution

0.4–1 cm ointment, topical, every 5–6 hr; 3–6 times daily

Ocular herpesvirus infection

200 mg/mL suspension for injection

10–30 mg/kg/day, IV, as CRI for 12–24 hr

Acyclovir

200-mg capsules or tablets

200 mg, PO, qid, every 4 hr, or 5 times daily

Feline herpesvirus

5% cutaneous ointment

Cover lesion, topical, every 3 hr, 6 times daily

200 mg/5 mL suspension

80 mg/kg/day (mixed with peanut butter), PO, for 7–14 days

Pacheco’s disease in birds

500 mg/vial powder

250–500 mg/m2, IV, tid, infused over at least 1 hr

Ganciclovir

500 mg/vial powder

2–5 mg/kg, IV, bid-tid

Ribavirin

11 mg/kg/day, IV, for 7 days

Susceptible viral infections

6 g/100 mL vial powder

Using SPAC-2 nebulizer only, inhalation, 8–18 hr period daily

Zidovudine

10 mg/mL syrup; 10 mg/mL injection

5–20 mg/kg (cats), PO or SC, bid-tid

FIV, FeLV

Amantadine

100- and 500-mg capsules

100 mg total (human), PO, once to twice daily

Syrup 10 mg/mL

100 mg/day total (juveniles), PO

Rimantadine

200–300 mg/day total (human), PO

Interferon α-2

3 × 106 IU/vial

3 × 106 IU/person/day, SC, IM; 0.5–5 U/kg/day, PO; 100,000 U/kg/day, SC

FeLV-associated disease

1 U/day, PO

FeLV appetite stimulant

15–30 U, PO, IM, SC, once daily on alternate weeks

FIP, FIV

CRI = constant-rate infusion; FeLV = feline leukemia virus; FIP = feline infectious peritonitis; FIV = feline immunodeficiency virus