Merck Manual

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Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals

Drugs Commonly Used to Treat Urinary Tract Infections in Small Animals

Drug

Suggested Dosage

Typical Antimicrobial Activity

Amoxicillin

11 mg/kg, PO, bid-tid

Staphylococci, streptococci, enterococci, Proteus, some E coli

Ampicillin

25 mg/kg, PO, tid

Staphylococci, streptococci, enterococci, Proteus, some E coli

Amoxicillin-clavulanic acid

25 mg/kg, PO, tid

Staphylococci, streptococci, enterococci, Proteus, some E coli

Cephalexin/cefadroxil

20–30 mg/kg, PO, bid-tid

Staphylococci, streptococci, Proteus, E coli, Klebsiella

Cefovecin

8 mg/kg, SC, every 14 days

Proteus, E coli

Cefpodoxime

5–10 mg/kg/day, PO

Proteus, E coli

Ceftiofur

2 mg/kg/day, SC

Proteus, E coli

Choramphenicol

Dogs: 25–50 mg/kg, PO, bid-tid

Cats: 50 mg/kg, PO, bid

Staphylococci, streptococci, enterococci, E coli

Doxycycline

5 mg/kg, PO, bid

Streptococci, some activity against E coli, staphylococci, and enterococci at high urine concentrations

Enrofloxacin, orbifloxacin, marbofloxacin, pradofloxacin (cats only)

2.5–10 mg/kg/day, PO

Staphylococci, E coli, Proteus, Klebsiella, Pseudomonas, Enterobacter

Gentamicin

4–6 mg/kg/day, SC

Staphylococci, some streptococci, some enterococci, E coli, Proteus, Klebsiella, Pseudomonas, Enterobacter

Nitrofurantoin

5 mg/kg, PO, tid

Staphylococci, some streptococci, enterococci, E coli, Klebsiella, Enterobacter

Tetracycline

18 mg/kg, PO, tid

Streptococci, some activity against E coli, staphylococci, and enterococci at high urine concentrations

Trimethoprim-sulfa

15 mg/kg, PO, bid

Streptococci, staphylococci, E coli, Proteus, some activity against Klebsiella