Merck Manual

Please confirm that you are a health care professional

Poisonous Mushrooms: Onset of Action and Organs Targeted

Poisonous Mushrooms: Onset of Action and Organs Targeted

Mushrooms

Toxin

Onset Time

Organ/System

Latent Period >6 hr After Ingestion; Life-threatening

Amanita phalloides; A virosa

Cyclopeptides, α and β amanitins, phallotoxins, virotoxins

6–24 hr, rarely >24 hr

Primarily liver, kidney secondary

Conocybe filaris

α and β amanitins

6–14 hr, rarely >24 hr

Primarily liver

Cortinarius gentilis

Orellanin, orelline

3–14 days (days/weeks)

Primarily renala

Galerina autumnalis; G venenata

α and β amanitins

6–14 hr, rarely >24 hr

Primarily liver

Gyromitra esculenta

Monomethylhydrazine

6–24 hr

CNS

Lepiota spp

α and β amanitins

6–14 hr, rarely >24 hr

Primarily liver

Latent Period ≤3 hr After Ingestion; Not Life-threatening

Amanita muscaria; A pantherina

Isoxazoles: ibotenic acid muscimol

30 min–2 hr; recovery 4–24 hr

CNS

Chlorophyllum molybdites

Unknown

30 min–3 hr; recovery 1–2 days

GI

Clitocybe dealbata; Clitocybe spp; Inocybe spp

Muscarine

30 min–2 hr; recovery 6–24 hr

Autonomic nervous system

Paxillus involutus

Unknown

1–3 hr; recovery 2–4 days

Immune system

Psilocybe spp; Conocybe smithii; Gymnopilus spectabilis; Panaeolus subbalteatus

Psilocybin and psilocin

30–60 min; rarely 6 hr

CNS

Russula emetica

Unknown

30 min–3 hr; recovery 1–2 days

GI

a No reported veterinary cases