Merck Manual

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Herbicides with Potential to Cause Developmental Toxicity in Experimental Animals

Herbicides with Potential to Cause Developmental Toxicity in Experimental Animals

Compound

Effects

Atrizine

Disruption of ovarian cycle and induced repetitive pseudopregnancy (rats, at high doses)

Buturon

Cleft palate, increased fetal mortality (mice)

Butiphos

Teratogenic (rabbit)

Chloridazon

Malformations

Chlorpropham

Malformations or other developmental toxicity (mice)

Cynazine

Malformations such as cyclopia and diaphragmatic hernia (rabbits); skeletal variations in rats

2,4-Da or 2,4,5-Ta alone or in combination

Malformations such as cleft palate, hydronephrosis; teratogenic (mice, rats)

Dichlorprop

Teratogenic (mice); affect postnatal behavior (rats)

Dinosebb

Multiple defects (mice, rabbits)

Dinoterb

Skeletal malformations (rats); skeletal, jaw, head, and visceral (rabbits)

Linuron

Malformations (rats)

Mecoprop

Malformations (mice only)

Monolinuron

Cleft palate (mice)

MCPAc

Teratogenic and embryotoxic (rats), teratogenic (mice)

Prometryn

Head, limbs, and tail defects (rat)

Propachlor

Slightly teratogenic (rats)

Nitrofenb

Malformations (mice, rats, hamsters)

Silvex

Teratogenic (mice)

TCDDa

Malformations/teratogenic (fetotoxicity in chickens, rats, mice, rabbits, guinea pigs, hamsters, and monkeys)

Tridiphane

Malformations such as cleft palate (mice); skeletal variations (rats)

a TCDD is a common contaminant during the manufacturing process of some herbicides such as 2,4-D and 2,4,5-T.

b Obsolete

c 2-methyl-4-chlorophenoxyacetic acid