Table: Drugs for Intestinal Helminths of Dogs Approved in the USA and UK

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Drugs for Intestinal Helminths of Dogs Approved in the USA and UK

Drug/Drug Combination	Dosage (mg/kg)	Route of Administration	Helminths Active Against^a
Approved only in USA
Fenbendazole	50, daily for 3 days	PO	Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala, Trichuris vulpis, Trichuris pisiformis
Epsiprantel	5.5	PO	D caninum, T pisiformis
Milbemycin oxime	0.5	PO	T canis, T leonina, A caninum, T vulpis
Milbemycin oxime + spinosad	0.5/30	PO	T canis, T leonina, A caninum, T vulpis
Moxidectin	0.17	SC	A caninum, U stenocephala
Piperazine (various salts)	48–66^{b, d}	PO	T canis, T leonina
Praziquantel	5–12.5	PO	D caninum, T pisiformis, Echinococcus granulosus^c, E multilocularis^c
	5–11.4	SC, IM	D caninum, T pisiformis, E granulosus, E multilocularis
Pyrantel pamoate	5 (10 for dogs ≤2.3 kg)	PO	T canis, T leonina, A caninum, U stenocephala
Ivermectin + pyrantel pamoate	0.006/5	PO	T canis, T leonina, A caninum, A braziliense, U stenocephala
Praziquantel + pyrantel pamoate	5/5	PO	T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis
Praziquantel + pyrantel pamoate + febantel	5/5/25	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis, D caninum, T pisiformis, E granulosus, E multilocularis
Praziquantel + pyrantel pamoate + ivermectin	5/5/0.006	PO	T canis, T leonina, A caninum, A braziliense, U stenocephala, D caninum, T pisiformis

*Approved only in UK*
Fenbendazole	100; 50, daily for 3 days	PO	T canis, T leonina, Ancylostoma spp, Uncinaria spp, Trichuris spp, Taenia spp
Praziquantel	5	PO	D caninum, T pisiformis, Taenia multiceps, T hydatigena, T ovis, E granulosus, E multilocularis
Selamectin	6	Topical	T canis
Febantel + pyrantel embonate	15/14.4	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis
Milbemycin oxime + praziquantel	0.5/5	PO	T canis, T leonina, A caninum, T vulpis, D caninum, Taenia spp, Echinococcus spp, Mesocestoides spp
Praziquantel + pyrantel embonate + febantel	5/14.4/15	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis^c, D caninum^c, Taenia spp (T hydatigena^c, T pisiformis^c), Echinococcus spp^c (E granulosus^c, E multilocularis^c)
Praziquantel + pyrantel embonate + oxantel embonate	5/5/20	PO	T canis, T leonina, A caninum, U stenocephala, T vulpis, D caninum, Taenia spp^c (Taenia ovis^c, T pisiformis^c, T hydatigena^c, T multiceps^c), Echinococcus spp^c (E granulosus^c, E multilocularis^c), Mesocestoides spp^c

*Approved both in USA and UK*
Milbemycin oxime + lufenuron	0.5/10	PO	T canis, T leonina^d, A caninum, T vulpis
Moxidectin + imidacloprid	2.5/10	Topical	T canis, T leonina, A caninum, U stenocephala, T vulpis, Spirocerca lupi^e
^a Many of these drugs are also approved for use against other types of parasites (eg, fleas, heartworm) not listed here.
^b Repeat in 10–20 days
^c Only some products
^d Only in the USA
^e Only in the UK

Merck Manual

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Drugs for Intestinal Helminths of Dogs Approved in the USA and UK