Granulated sugar

• Inflammatory to early repair phase

• Hyperosmotic

• Requires frequent bandage changes

Honey

• Inflammatory to early repair phase

• Hyperosmotic effect may damage healthy tissue

• Requires frequent bandage changes

Silver

• Inflammatory and repair phases

• No clinical evidence of resistance

Antibiotics

• Inflammatory and repair phases

• Broad spectrum

• May also supply zinc to the wound environment

Enzymatic agents

• Inflammatory phase

• Slow

• Expensive

Biological (maggot therapy)

• Inflammatory phase

• Selective debridement

• Requires specialized dressing to contain the maggots