Coccidioidomycosis is primarily a chronic respiratory disease, but canine infections can spread to many tissues, especially eyes, joints, and bone. Dogs with generalized disease may have the following signs:

• Chronic cough

• Loss of appetite

• General ill health and malnutrition

• Lameness

• Enlarged joints

• Fever

• Intermittent diarrhea

• Spread to the skin with draining ulceration may occur (primary infection through the skin is rare)