Merck Manual

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Dawn Merton Boothe

, DVM, PhD, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

Last full review/revision Nov 2015 | Content last modified Nov 2015

The streptogramin antibiotics include two distinct groups. Group A contain a 23-membered unsaturated ring with lactone and peptide bonds, and group B are depsipeptides (lactone-cyclized peptides). These antibiotics are included in the macrolide-lincosamide-streptogramin (MLS) group. However, whereas the individual A and B components act in a bacteriostatic fashion when used as sole agents, together the affinity for the ribosome is enhanced, causing them to be bactericidal. Streptogramins include virginiamycin. Streptogramins are used to treat vancomycin-resistant staphylococci and Enterococcus faecium.

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