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Find information on animal health topics, written for the veterinary professional.

Penciclovir and Famciclovir

By Dawn Merton Boothe, DVM, PhD, Professor, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

Famciclovir is the prodrug form of penciclovir. Penciclovir is very similar to acyclovir in terms of mechanism of action and spectrum. Although it is much less potent than acyclovir, penciclovir accumulates to much higher concentrations inside the cell. Penciclovir has been studied in cats receiving famciclovir at 62.5 mg for 3 days; it appeared to be well tolerated.