Merck Manual

Please confirm that you are a health care professional

honeypot link

Ribavirin

By

Dawn Merton Boothe

, DVM, PhD, Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University

Last full review/revision Nov 2015 | Content last modified Nov 2015

Ribavirin is a synthetic triazole nucleoside (an analogue of guanosine) with a broad spectrum of activity against many RNA and DNA viruses, both in vitro and in vivo. Susceptible viruses include adenoviruses, herpesviruses, orthomyxoviruses, paramyxoviruses, poxviruses, picornaviruses, rhabdoviruses, rotaviruses, and retroviruses. Viral resistance to ribavirin is rare. The action of ribavirin involves specific inhibition of viral-associated enzymes, inhibition of the capping of viral mRNA, and inhibition of viral polypeptide synthesis. It is well absorbed, widely distributed in the body, eliminated by renal and biliary routes as both parent drug and metabolites, and has a plasma half-life of 24 hr in people. It does not have a wide margin of safety in domestic animals. Toxicity is manifest by anorexia, weight loss, bone marrow depression and anemia, and GI disturbances. It has been successfully administered by topical, parenteral, oral, and aerosol routes. Efficacy depends on the site of infection, method of treatment, age of the animal, and infecting dose of virus. Results of human influenza studies with ribavirin have been equivocal.

Others also read
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Test your knowledge

Antibacterial Agents
Administration of which of the following systemic antibiotics is most suitable for canine otitis caused by Pseudomonas aeruginosa?
Become a Pro at using our website 

Also of Interest

Become a Pro at using our website 
TOP